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Image Search Results


m6A mRNA Epitranscriptomic Microarray analysis. A-C : Hierarchical clustering heatmap of EMCI/Control ( A ), LMCI/Control ( B ), and LMCI/EMCI ( C ). Each row represented one mRNA, and each column represented one sample. D-F : Volcano plot analysis of EMCI/Control ( D ), LMCI/Control ( E ), and LMCI/EMCI ( F ). Red boxes represented upregulated transcripts (≥ 1.5-fold change, P < 0.05), and blue boxes represented downregulated transcripts (≤ 0.7-fold change, P < 0.05). G-I : Four-quadrant diagram of changed transcripts in both m6A methylation and mRNA expression of EMCI/Control ( G ), LMCI/Control ( H ), and LMCI/EMCI ( I ). Red dots: hypermethylated-upregulated mRNAs; green dots: hypermethylated-downregulated mRNAs; purple dots: hypomethylated-upregulated mRNAs; blue dots: hypomethylated-downregulated mRNAs. P < 0.05. J-L : The interaction between m6A methylation and mRNA expression. ( J ) Hypermethylation-upregulation, ( K ) Hypomethylation-upregulation, ( L ) Hypomethylation-downregulation

Journal: Alzheimer's Research & Therapy

Article Title: Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine

doi: 10.1186/s13195-025-01743-5

Figure Lengend Snippet: m6A mRNA Epitranscriptomic Microarray analysis. A-C : Hierarchical clustering heatmap of EMCI/Control ( A ), LMCI/Control ( B ), and LMCI/EMCI ( C ). Each row represented one mRNA, and each column represented one sample. D-F : Volcano plot analysis of EMCI/Control ( D ), LMCI/Control ( E ), and LMCI/EMCI ( F ). Red boxes represented upregulated transcripts (≥ 1.5-fold change, P < 0.05), and blue boxes represented downregulated transcripts (≤ 0.7-fold change, P < 0.05). G-I : Four-quadrant diagram of changed transcripts in both m6A methylation and mRNA expression of EMCI/Control ( G ), LMCI/Control ( H ), and LMCI/EMCI ( I ). Red dots: hypermethylated-upregulated mRNAs; green dots: hypermethylated-downregulated mRNAs; purple dots: hypomethylated-upregulated mRNAs; blue dots: hypomethylated-downregulated mRNAs. P < 0.05. J-L : The interaction between m6A methylation and mRNA expression. ( J ) Hypermethylation-upregulation, ( K ) Hypomethylation-upregulation, ( L ) Hypomethylation-downregulation

Article Snippet: The cRNAs were combined and hybridized onto Arraystar Human mRNA Epitranscriptomic Microarray (8 × 60 K, Arraystar).

Techniques: Microarray, Control, Methylation, Expressing